MK-677

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butamoren (also known as ibutamoren mesylate or MK-677), promotes the secretion of the growth hormone (GH) and increases insulin-like growth factor 1

Ibutamoren increases growth hormone levels by mimicking the action of the hormone ghrelin and binding to one of the ghrelin receptors (GHSR) in the brain. Activated GHSR stimulates growth hormone release from the brain.

GHSR is found in brain regions that control appetite, pleasure, mood, biological rhythms, memory, and cognition [R]. Therefore, we can expect that ibutamoren may also affect these functions. However, so far, clinical studies describe only the effects ibutamoren has on appetite – and as expected, like ghrelin, ibutamoren increases it.

A great thing about ibutamoren is that it increases growth hormone levels with little or no increase in other hormones, such as cortisol [RR]. Cortisol suppresses the immune system, reduces wound healing, and impairs learning and memory, and it’s usually not good to have this hormone elevated.

Uses of Ibutamoren

1) Building Muscle

Ibutamoren is frequently used as an anabolic substance, to increase lean body mass i.e. create bigger muscles. It is orally active and can be taken once a day. These are all benefits compared to other growth hormone stimulators.

As previously mentioned, ibutamoren increases growth hormone levels and IGF-1 [RR]. Both growth hormone and IGF-1, in turn, increase muscle mass, muscle strength, and reduce body fat [RR, R].

In 24 obese men, a two-month treatment (DB-RCT) with ibutamoren increased lean mass, and transiently increased basal metabolic rate (BMR) [R].

2) Muscle Wasting

In a study (DB-RCT) in eight food-deprived healthy volunteers, ibutamoren reversed diet-induced protein loss [R], that could cause muscle wasting.

In 123 elderly patients with hip fracture, ibutamoren improved gait speed, muscle strength and reduced the number of falls (RCT) [R].

3) Bone Density

Growth hormone (GH) increases bone turnover and eventually bone density [R]. However, because of the increased turnover in subjects treated with growth hormone, bone density can initially decrease before increasing [R]. Basically, it takes time (> 1 year) to see the bone density increase.

In 24 healthy obese male volunteers, ibutamoren increased bone turnover (DB-RCT) [R].

In 187 elderly adults (65 years or older), ibutamoren increased bone building, as measured by osteocalcin, a marker of bone turnover in multiple studies (3 DB-RCTs) [R].

In one study (DB-RCT) with 292 post-menopausal women, ibutamoren increased bone mineral density, which helps increase bone strength and prevent osteoporosis [R].

4) Sleep

A study (DB-PCT) showed that in both younger and elderly subjects, ibutamoren improved sleep quality and REM (rapid eye movement) sleep duration [R].

Apart from scientific studies, there have been many reports of subjective improvements in sleep quality, across various online forums.

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5) Longevity

Growth Hormone (GH) secretion and muscle mass both decline from mid-puberty throughout life [R].

In a study with 65 elderly men and women (DB-RCT), daily ibutamoren increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects [R]. IGF-1 is known to have beneficial effects on longevity [RR].

In another study with 24 obese males (DB-RCT), ibutamoren rejuvenated the growth hormone profile [R].

6) Nootropic Effects

Some people use ibutamoren as a nootropic because it acts on the ghrelin receptor, which has nootropic effects. You can read more about these effects in the post on ghrelin. Science is, however, yet to study if and how ibutamoren affects cognitive performance.

Two indirect mechanisms by which ibutamoren can improve brain function:

  • Ibutamoren increases IGF-1, which is known to improve memory and learning [RR].
  • Ibutamoren also increases REM sleep duration and sleep quality [R]. And we know that sleep is essential for good cognitive function [R].

A study (DB-multicenter) questioned the association of low IGF-1 and Alzheimer’s disease, and whether ibutamoren could be of help. However, in this study, ibutamoren was ineffective at slowing the progression of Alzheimer’s in humans [R].

7) Growth Hormone Deficiency

Ibutamoren can increase growth hormone, IGF-1, and IGFBP-3 levels in children with growth hormone deficiency. Furthermore, these effects are achieved without changing the concentrations of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin,  cortisol or insulin [R].

In severely GH-deficient men, ibutamoren increased IGF-1 and growth hormone, with no significant changes in cortisol, PRL, and thyroid hormone levels. However, insulin and glucose were increased (DB-RCT) [R].

8) Wound Healing and Tissue Regeneration

Growth hormone increases tissue regeneration and wound healing [RR], so ibutamoren may help with these.

There are individual reports of ibutamoren being helpful, but scientific studies are lacking.

9) Hangovers

This one is anecdotal, but people report curing hangovers with ibutamoren.

Side Effects

The most frequent side effects of ibutamoren are an increase in appetite and transient, mild lower extremity edema and muscle pain [R].

Several studies report an increase in fasting blood glucose and a decrease in insulin sensitivity [RR].

These side effects are similar to those observed in people with elevated growth hormone levels, mainly joint pain and insulin resistance [RR].

Although most studies report little or no side effects, one study was terminated because of serious adverse events. In elderly patients with hip fracture, ibutamoren elevated blood pressure, blood glucose and HbA1c, and there were cases of congestive heart failure [R]. The patients experiencing congestive heart failure were over 80 and had a history of prior heart failure.

It would be prudent to watch your carbohydrate intake and regularly check blood sugar and insulin levels while taking ibutamoren.

As an anabolic, ibutamoren should be avoided if you have cancer. Both growth hormone and IGF-1 may promote cancer growth.

I would not take ibutamoren if you are Th1 dominant since growth hormone has immune stimulatory properties.

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